Eimoto T, Teshima K, Shirakusa T, Kikuchi M
Ultrastruct Pathol. 1985;8(2-3):177-90. doi: 10.3109/01913128509142151.
The cytologic phenotypes of 20 well-differentiated pulmonary adenocarcinomas were determined by electron microscopy. On examination of more than 100 cells in each case, the tumors were classified according to the predominant cell types. Nine cases (45%) were of mucous cell type, further divided into 7 cases of bronchial surface epithelial cell type, 1 case of bronchial gland cell type, and 1 case of metaplastic bronchiolar goblet cell type. The remainder included 5 cases (25%) of Clara cell type, 2 cases (10%) of type II cell type, and 4 cases (20%) of mixed cell type. The predominant histologic pattern by light microscopy was "typically" bronchioloalveolar (Manning et al.'s type 1) in the metaplastic goblet cell tumor and papillary in most Clara cell-type tumors, while it was glandular in bronchial surface and bronchial gland cell types, although variable in type II cell or mixed cell type. Therefore, bronchioloalveolar carcinomas, when histologically defined inclusive of papillary tumors, present cytologic phenotypes also related to the bronchioloalveolar epithelium, i.e., metaplastic goblet or Clara or type II cell subtypes, which is in accordance with some previous reports. These tumors could be distinguished from the other (glandular) adenocarcinomas that show primarily bronchial mucous cell differentiation.
通过电子显微镜确定了20例高分化肺腺癌的细胞表型。在每例检查100多个细胞后，根据主要细胞类型对肿瘤进行分类。9例（45%）为黏液细胞型，进一步分为支气管表面上皮细胞型7例、支气管腺细胞型1例和化生细支气管杯状细胞型1例。其余包括5例（25%）克拉拉细胞型、2例（10%）II型细胞型和4例（20%）混合细胞型。光镜下主要的组织学模式在化生杯状细胞肿瘤中为“典型的”细支气管肺泡型（Manning等的1型），在大多数克拉拉细胞型肿瘤中为乳头状，而在支气管表面和支气管腺细胞型中为腺管状，在II型细胞或混合细胞型中则有所不同。因此，当组织学定义的细支气管肺泡癌包括乳头状肿瘤时，其细胞表型也与细支气管肺泡上皮有关，即化生杯状细胞或克拉拉细胞或II型细胞亚型，这与一些先前的报道一致。这些肿瘤可与主要表现为支气管黏液细胞分化的其他（腺管状）腺癌相鉴别。
