Baisden B L, Hamper U M, Ali S Z
John K. Frost Cytopathology Laboratory, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21287-6940, USA.
Diagn Cytopathol. 1999 May;20(5):291-4. doi: 10.1002/(sici)1097-0339(199905)20:5<291::aid-dc8>3.0.co;2-r.
Pulmonary metastasis of intracranial meningioma is rare. We present the cytomorphologic features of such a tumor in a 71 yr-old woman who was found to have multiple lung nodules 13 years following the resection of an atypical intracranial meningioma. Cytomorphologic features were quite distinct and included hypercellularity with large syncytial groups of monomorphic cells with epithelioid morphologic features, often in perivascular arrangements. Occasional intranuclear cytoplasmic inclusions as well as binucleated cells with wispy cytoplasmic extensions were also noted. Immunoperoxidase studies showed focal positivity for epithelial membrane antigen. The differential diagnosis includes primary or metastatic adenocarcinoma, malignant mesothelioma, and melanoma.
颅内脑膜瘤的肺转移罕见。我们报告了一名71岁女性患者的此类肿瘤的细胞形态学特征，该患者在非典型颅内脑膜瘤切除13年后发现有多个肺结节。细胞形态学特征非常独特，包括细胞增多，有大量具有上皮样形态特征的单形性细胞形成的合体细胞群，常呈血管周围排列。还注意到偶尔出现核内胞质包涵体以及带有纤细胞质突起的双核细胞。免疫过氧化物酶研究显示上皮膜抗原呈局灶性阳性。鉴别诊断包括原发性或转移性腺癌、恶性间皮瘤和黑色素瘤。
