Kasahara M
Department of Biosystems Science, Graduate University for Advanced Studies, Hayama, Japan.
Immunol Rev. 1999 Feb;167:17-32. doi: 10.1111/j.1600-065x.1999.tb01379.x.
The major histocompatibility complex (MHC) is a genetic region that has been extensively studied by immunologists, molecular biologists, and evolutionary biologists. Nevertheless, our knowledge of how the MHC acquired its present-day organization is quite limited. The recent discovery that the mammalian genome contains regions paralogous to the MHC has led us to the proposal that the MHC region of jawed vertebrates arose as a result of ancient chromosomal duplications. Here, I review the current status of this proposal.
主要组织相容性复合体（MHC）是一个基因区域，免疫学家、分子生物学家和进化生物学家对其进行了广泛研究。然而，我们对MHC如何获得其当前组织形式的了解相当有限。最近发现哺乳动物基因组中含有与MHC同源的区域，这使我们提出有颌脊椎动物的MHC区域是古代染色体复制的结果。在此，我回顾这一观点的现状。
