卡波罗孟对心脏游离脂肪酸代谢的影响。

Influence of carbocromene on free fatty acid metabolism of the heart.

作者信息

Schraven E

出版信息

Recent Adv Stud Cardiac Struct Metab. 1976;11:363-7.

PMID:1031936

Abstract

In view of the fact that carbocromene (C) influences the metabolic processes in the heart muscle, its effect on the transport of substrates into the heart tissue was investigated. In rat heart slices C inhibits the uptake of [1-14C]palmitic acid up to 40%, while 14CO2 production is reduced to the same extent. At the same time oxygen consumption diminished by about 20%. Using 3-O-[14C] methyl-D-glucose as metabolic marker it was shown that the uptake of glucose into the heart tissue increased by 30% under the influence of C. From these results it can be concluded that C inhibits the oxidation of FFA in favor of glucose and diminishes the oxygen-wasting effect of FFA.

摘要

鉴于卡波罗孟（C）会影响心肌中的代谢过程，因此研究了其对底物转运至心脏组织的作用。在大鼠心脏切片中，C可将[1-14C]棕榈酸的摄取抑制达40%，同时14CO2生成量也减少至相同程度。与此同时，耗氧量减少了约20%。使用3-O-[14C]甲基-D-葡萄糖作为代谢标志物表明，在C的作用下，心脏组织对葡萄糖的摄取增加了30%。从这些结果可以得出结论，C抑制脂肪酸氧化而有利于葡萄糖，并减少了脂肪酸的耗氧效应。