Siess M
Basic Res Cardiol. 1980 Jan-Feb;75(1):47-56. doi: 10.1007/BF02001393.
FFA are the main substrate of biological oxidation in cardiac muscle under normal conditions. But it could be shown in man and animal that during heavy exercise there is a shift to preferential oxidation of lactate. During oxygen deficiency in hypoxic or ischemic situations which may occur lightly in distinct areas of hypertrophic hearts after exercise, lactate, alpha-glycerol phosphate and acyl-CoA as well as triglyceride levels in cardiac tissue may increase, whereas FFA are less oxidized. Unoxidized intracellular FFA and acyl-CoA, which are not esterified in a sufficient way to triglycerides, may impair oxidative phosphorylation in mitochondria, the P/O quotient as well as cardiac function perhaps by an interference with Ca++ movements during the contraction cycle. With the examples of anoxia and complete ischemia as the two extreme situations of O2 deficiency some principles of the alteration of cardiac metabolism are pointed out, and furthermore attempts to improve anoxic tolerance of cardiac tissue.
在正常情况下，游离脂肪酸（FFA）是心肌生物氧化的主要底物。但在人和动物中可以发现，在剧烈运动时会转向优先氧化乳酸。在缺氧或缺血情况下出现氧缺乏时，这在运动后肥厚心脏的不同区域可能会轻度发生，心脏组织中的乳酸、α-甘油磷酸、酰基辅酶A以及甘油三酯水平可能会升高，而游离脂肪酸的氧化则减少。未氧化的细胞内游离脂肪酸和酰基辅酶A，它们没有以足够的方式酯化为甘油三酯，可能会损害线粒体中的氧化磷酸化、P/O比值以及心脏功能，可能是通过在收缩周期中干扰钙离子运动。以缺氧和完全缺血这两种氧缺乏的极端情况为例，指出了心脏代谢改变的一些原则，此外还尝试提高心脏组织的缺氧耐受性。
