地尔硫䓬对离体兔主动脉中钙和去甲肾上腺素诱导收缩的影响。
Effect of diltiazem on calcium- and noradrenaline-induced contractions in isolated rabbit aorta.
作者信息
Nagao T, Ikeo T, Sato M, Nakajima H, Kiyomoto A
出版信息
Recent Adv Stud Cardiac Struct Metab. 1976;11:437-40.
The effect of diltiazem on calcium- and noradrenaline-induced contractions was investigated in the K-depolarized aortic strip of the rabbit. Diltiazem inhibited the contraction induced by calcium ions dose-dependently. A lower concentration of diltiazem produced no significant influence on the contraction induced by noradrenaline, while a higher concentration suppressed it. It is assumed that in the rabbit aorta diltiazem effectively inhibits the contraction mediated by the influx of calcium ions but it is less effective with the contraction induced by the release of sequestered calcium.
在兔的钾离子去极化主动脉条上研究了地尔硫䓬对钙和去甲肾上腺素诱导的收缩作用。地尔硫䓬剂量依赖性地抑制钙离子诱导的收缩。较低浓度的地尔硫䓬对去甲肾上腺素诱导的收缩无显著影响，而较高浓度则抑制该收缩。据推测，在兔主动脉中，地尔硫䓬有效地抑制由钙离子内流介导的收缩，但对由储存钙释放诱导的收缩效果较差。
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