Ohashi M, Takayanagi I, Sekine A, Okumura K, Iwata H
J Pharmacobiodyn. 1983 Jul;6(7):487-95. doi: 10.1248/bpb1978.6.487.
The effects of sodium nitroprusside (NaNP) and diltiazem on CaCl2-,KCl- and histamine-induced contractile responses were studied in isolated rabbit basilar artery, aorta, taenia coli and trachea. NaNP reduced CaCl2-induced maximal contractions in basilar artery and aorta, but little affected those in taenia coli and trachea. NaNP reduced histamine-induced maximal contraction markedly in aorta but slightly in basilar artery and taenia coli. The reduction in aorta was reversed by increasing CaCl2 contraction in bathing medium. NaNP inhibited histamine-induced contractions of basilar artery, aorta and taenia coli in Ca-free medium. Diltiazem reduced CaCl2-induced maximal contractions in basilar artery and aorta, whilst it caused a parallel shift of concentration-response curves for CaCl2 to the right in taenia coli and trachea. diltiazem reduced histamine-induced maximal contractions in basilar artery and taenia coli. These reductions were reversed by increasing CaCl2 concentration in bathing medium. Diltiazem strongly inhibited histamine-induced contraction of taenia coli in Ca-free medium. The effects of NaNP and diltiazem on KCl-induced contractions both in normal (Ca; 2.5 mM) and in high Ca (Ca; 12.5 mM) media were also studied. From the results obtained in this study, the actions of NaNP and diltiazem were considered to vary with the type of smooth muscle or the condition eliciting contraction. Their possible mechanisms were discussed in this paper.
研究了硝普钠（NaNP）和地尔硫䓬对离体兔基底动脉、主动脉、结肠带和气管中氯化钙、氯化钾和组胺诱导的收缩反应的影响。NaNP降低了氯化钙诱导的基底动脉和主动脉的最大收缩，但对结肠带和气管的影响很小。NaNP显著降低了组胺诱导的主动脉最大收缩，但对基底动脉和结肠带的影响较小。在浴液中增加氯化钙收缩可逆转主动脉的这种降低。NaNP在无钙培养基中抑制组胺诱导的基底动脉、主动脉和结肠带收缩。地尔硫䓬降低了氯化钙诱导的基底动脉和主动脉的最大收缩，而在结肠带和气管中它使氯化钙浓度-反应曲线平行右移。地尔硫䓬降低了组胺诱导的基底动脉和结肠带的最大收缩。在浴液中增加氯化钙浓度可逆转这些降低。地尔硫䓬在无钙培养基中强烈抑制组胺诱导的结肠带收缩。还研究了NaNP和地尔硫䓬在正常（钙；2.5 mM）和高钙（钙；12.5 mM）培养基中对氯化钾诱导的收缩的影响。从本研究获得的结果来看，NaNP和地尔硫䓬的作用被认为随平滑肌类型或引发收缩的条件而变化。本文讨论了它们可能的机制。
