Holland P M, Cooper J A
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington, 98109, USA.
Curr Biol. 1999 May 6;9(9):R329-31. doi: 10.1016/s0960-9822(99)80205-x.
The substrate specificities of protein kinases have been found, in many cases, to be determined at least in part by short regions within the substrate known as docking sites. Docking sites are specific and modular, and can dramatically increase the efficiency of phosphorylation.
在许多情况下,已发现蛋白激酶的底物特异性至少部分由底物中称为对接位点的短区域决定。对接位点具有特异性且呈模块化,可显著提高磷酸化效率。