Xu L, Glass C K, Rosenfeld M G
Howard Hughes Medical Institute, Biomedical Sciences PhD Program, University of California at San Diego, La Jolla, California 92093-0648, USA.
Curr Opin Genet Dev. 1999 Apr;9(2):140-7. doi: 10.1016/S0959-437X(99)80021-5.
The nuclear hormone receptors constitute a large family of transcription factors. The binding of the hormonal ligands induces nuclear receptors to assume a configuration that leads to transcriptional activation. Recent studies of retinoic acid and thyroid hormone receptors revealed that, upon ligand binding, a histone deacetylase (HDAC)-containing complex is displaced from the nuclear receptor in exchange for a histone acetyltransferase (HAT)-containing complex. These observations suggest that ligand-dependent recruitment of chromatin-remodeling activity serves as a general mechanism underlying the switch of nuclear receptors from being transcriptionally repressive to being transcriptionally active.
核激素受体构成了一个庞大的转录因子家族。激素配体的结合会诱导核受体呈现出一种导致转录激活的构象。最近对视黄酸和甲状腺激素受体的研究表明，在配体结合后，一个含有组蛋白去乙酰化酶（HDAC）的复合物会从核受体上被置换下来，取而代之的是一个含有组蛋白乙酰转移酶（HAT）的复合物。这些观察结果表明，依赖配体的染色质重塑活性的募集是核受体从转录抑制状态转变为转录激活状态的普遍机制。
