作为多种共激活因子复合物控制面板的RNA聚合酶II
RNA polymerase II as a control panel for multiple coactivator complexes.
作者信息
Hampsey M, Reinberg D
机构信息
Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA.
出版信息
Curr Opin Genet Dev. 1999 Apr;9(2):132-9. doi: 10.1016/S0959-437X(99)80020-3.
1999 marks the 30th anniversary of the reported discovery of sigma factor and the bacterial RNA polymerase holoenzyme. In 1994, an RNA polymerase II complex was discovered in yeast - mammalian complexes were subsequently identified. Recent developments regarding the composition and function of RNA polymerase II complexes suggest, however, that the concept of the holoenzyme, as defined in bacteria, might not be relevant to eukaryotes.
1999年是报道发现σ因子和细菌RNA聚合酶全酶30周年。1994年，在酵母中发现了RNA聚合酶II复合物，随后鉴定出了哺乳动物复合物。然而，关于RNA聚合酶II复合物组成和功能的最新进展表明，细菌中定义的全酶概念可能与真核生物无关。
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