Dobie K W, Hari K L, Maggert K A, Karpen G H
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Curr Opin Genet Dev. 1999 Apr;9(2):206-17. doi: 10.1016/S0959-437X(99)80031-8.
Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere structure, kinetochore formation, and the coordination of chromosome inheritance with the cell cycle in several organisms. A picture is beginning to emerge of the centromere-kinetechore as a complex and dynamic structure with conservation of function at the protein level across diverse species.
着丝粒以及与之相关的动粒参与染色体传递的关键环节。最近的进展包括在几种生物体中鉴定和了解了在着丝粒结构、动粒形成以及染色体遗传与细胞周期协调过程中起关键作用的蛋白质。一幅关于着丝粒 - 动粒的图景正开始浮现，它是一个复杂且动态的结构，在不同物种间蛋白质水平上功能具有保守性。
