Jacobson S, Pillus L
Department of Biology 0347, University of California at San Diego, 2100A Pacific Hall, 9500 Gilman Drive, La Jolla, California 92093-0347, USA.
Curr Opin Genet Dev. 1999 Apr;9(2):175-84. doi: 10.1016/S0959-437X(99)80027-6.
A wave of biochemical and genetic progress has identified proteins that influence transcription by modifying chromatin. Many such factors are broadly conserved and, strikingly, occur in human diseases as partners in chromosomal translocations. Understanding the function of these factors will be key to defining mechanisms of transcriptional regulation and understanding cancers linked to aberrant chromatin modification.
一波生化和遗传学进展已鉴定出通过修饰染色质来影响转录的蛋白质。许多这类因子具有广泛的保守性，而且引人注目的是，它们在人类疾病中作为染色体易位的伙伴出现。了解这些因子的功能将是确定转录调控机制以及理解与异常染色质修饰相关癌症的关键。
