发动蛋白螺旋

Dynamin spirals.

作者信息

Hinshaw J E

机构信息

Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Curr Opin Struct Biol. 1999 Apr;9(2):260-7. doi: 10.1016/S0959-440X(99)80036-0.

DOI:10.1016/S0959-440X(99)80036-0

PMID:10322220

Abstract

Dynamin is an important component of membrane recycling at the plasma membrane and, potentially, within the cell. The role of dynamin in clathrin-mediated endocytosis has been based on numerous endocytosis assays, as well as on the discovery and gross characterization of the assembled spiral structure of dynamin. Recently, it has been shown that dynamin can also bind to liposomes and form helical tubes that constrict and vesiculate upon GTP addition. This suggests that dynamin is capable of and may be responsible for the pinching off of clathrin-coated vesicles from the plasma membrane during clathrin-mediated endocytosis.

摘要

发动蛋白是质膜以及细胞内潜在的膜循环的重要组成部分。发动蛋白在网格蛋白介导的内吞作用中的作用基于众多内吞试验，以及发动蛋白组装螺旋结构的发现和总体表征。最近，研究表明发动蛋白也能与脂质体结合并形成螺旋管，在添加鸟苷三磷酸（GTP）时会收缩并形成囊泡。这表明发动蛋白有能力且可能负责在网格蛋白介导的内吞作用过程中从质膜上掐断网格蛋白包被的囊泡。