Fang P, Wang B C, Wu C Y, Wan W X, Jiang N Y, Zhou X, Chen Z P
State Key Laboratory of Nuclear Medicine, Jiangsu, Peoples Republic of China.
J Nucl Med Technol. 1999 Mar;27(1):54-6.
The biological properties of a new neutral myocardial imaging agent 99mTcN(NOEt)2 were evaluated.
Blood clearance in rabbits, biodistribution in rats, and initial myocardial imaging in dogs were performed.
Radiochemical purity of 99mTcN(NOEt)2 was more than 90% and stable for 6 h at room temperature. Blood disappearance was analyzed with a biexponential model and T1/2(alpha) = 2.53 min, T1/2(beta) = 330 min and CI = 378 ml/h were obtained. Biodistribution studies demonstrated that 99mTcN(NOEt)2 localized selectively in the rat myocardium. Cardiac uptakes were 4.69, 4.20, 3.95 and 3.43% ID/g at 5, 30, 60 and 90 min postinjection, respectively. The mean heart-to-lung activity ratios were 1.69, 2.40 and 2.55 at 10 min, 30 min and 60 min postinjection, respectively.
Technetium-99m-N(NOEt)2 exhibited favorable stability and biological properties. Further study in humans is required.
评估一种新型中性心肌显像剂99mTcN(NOEt)2的生物学特性。
进行了家兔的血液清除、大鼠的生物分布及犬的首次心肌显像。
99mTcN(NOEt)2的放射化学纯度大于90%，在室温下6小时内稳定。采用双指数模型分析血液清除情况，得出T1/2(α)=2.53分钟，T1/2(β)=330分钟，CI=378毫升/小时。生物分布研究表明，99mTcN(NOEt)2选择性地定位于大鼠心肌。注射后5、30、60和90分钟时，心脏摄取率分别为4.69%、4.20%、3.95%和3.43% ID/g。注射后10、30和60分钟时，心脏与肺的平均放射性活度比分别为1.69、2.40和2.55。
锝-99m-N(NOEt)2显示出良好的稳定性和生物学特性。需要在人体中进行进一步研究。
