Liu Y, Xu Z, Ouyang P
Department of Epidemiology, Shanghai Medical University.
Zhonghua Yu Fang Yi Xue Za Zhi. 1998 May;32(3):162-4.
The possibility of re-immunization with a booster dose of live attenuated hepatitis A (HA) vaccine was studied.
Children randomly sampled were divided into three groups with re-immunization, primary immunization and immunity via natural infection. Antibodies against hepatitis A virus (anti-HAV) were detected qualitatively and quantitatively with modified Abbott enzyme immunoassay (EIA).
Proportion of children with positive anti-HAV and its mean geometric titer (GMT) increased within two weeks after re-immunization, and as compared, those increased slowly and GMT reached the peak three months after primary immunization. Response to the live attenuated vaccine differed between the groups of re-immunization and immunity via natural infection, and should be taken into consideration in studying immune persistence of the vaccine. Proportion of children, who converted negative of their anti-HAV after primary immunization, with positive anti-HAV after re-immunization was 83.3% (10/12), significantly higher than that in those who failed in primary immunization and then were vaccinated again (50%, with 17/34), and that in both of them were higher than in primary immunization (29.6%).
Reminiscence could be induced by re-immunization, and the effects of it depended on primary immunization. Detection of anti-HAV with modified Abbott EIA still underestimated primary immune reaction. A more sensitive and specific method for detecting anti-HAV after vaccination should be used.
研究给予一剂甲型肝炎（HA）减毒活疫苗加强免疫的再免疫可能性。
随机抽取儿童分为再免疫组、初次免疫组和自然感染免疫组。采用改良雅培酶免疫测定法（EIA）对甲型肝炎病毒抗体（抗-HAV）进行定性和定量检测。
再免疫后两周内抗-HAV阳性儿童比例及其平均几何滴度（GMT）升高，相比之下，初次免疫后升高缓慢，GMT在三个月时达到峰值。再免疫组和自然感染免疫组对减毒活疫苗的反应不同，在研究疫苗免疫持久性时应予以考虑。初次免疫后抗-HAV转阴的儿童再免疫后抗-HAV阳性比例为83.3%（10/12），显著高于初次免疫失败后再次接种的儿童（50%，17/34），且二者均高于初次免疫时（29.6%）。
再免疫可诱导回忆反应，其效果取决于初次免疫。改良雅培EIA检测抗-HAV仍低估了初次免疫反应。应采用更灵敏、特异的方法检测接种疫苗后的抗-HAV。
