非胰岛素依赖型糖尿病患者中医证型及其与超氧化物歧化酶和丙二醛相关性的研究
[Study on syndrome-type in TCM and its correlation with superoxide dismutase and malonyldialdehyde in patients with non-insulin dependent diabetes mellitus].
作者信息
Jiang Z S, Zhang S L, Yan H
机构信息
General Hospital of Jinan Military Region, Peoples Liberation Army.
出版信息
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Oct;17(10):597-8.
OBJECTIVE
To explore the possible relationship between Syndrome-Type in TCM and the superoxide dismutase (SOD) as well as malonyldialdehyde (MDA).
METHODS
Serum SOD and MDA were measured in 61 patients with non-insulin dependent diabetes mellitus (NIDDM) and 20 normal subjects.
RESULTS
SOD activity of the NIDDM patients blood were clearly lower than those of normal subjects, but MDA were markedly elevated. From the Syndrome-Type of Yin Deficiency with Hyperactivity of Heat, to both Qi and Yin Deficiency, to both Yin and Yang Deficiency, or from without hemostasis to with the appearance of hemostasis in order. The SOD activity decreased and meanwhile MDA increased gradually.
CONCLUSIONS
SOD activity and MDA levels in patients with NIDDM were associated with Syndrome-Type in TCM, it might be responsible for the diagnosis of Syndrome-Type in TCM.
目的
探讨中医证型与超氧化物歧化酶（SOD）及丙二醛（MDA）之间的可能关系。
方法
测定61例非胰岛素依赖型糖尿病（NIDDM）患者和20例正常受试者的血清SOD和MDA。
结果
NIDDM患者血液中的SOD活性明显低于正常受试者，而MDA则显著升高。从阴虚热盛证型，到气阴两虚证型，再到阴阳两虚证型，或从无瘀血到出现瘀血依次变化。SOD活性逐渐降低，同时MDA逐渐升高。
结论
NIDDM患者的SOD活性和MDA水平与中医证型相关，可能有助于中医证型的诊断。
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