[Rostral ventrolateral medulla-sympathetic vasoconstrictor nerve system mediated insular cortex-pressor response].

In urethane-anesthetized, tubocurarine-immobilized and artificially ventilated rats, microinjection of L-glutamate (Glu) into the insular cortex (INS) caused a rise in blood pressure and heart rate. Bilateral injection of either phentolamine, propranolol or atropine into the rostral ventrolateral medulla (RVL) all could decrease the INS-pressor response. The latter could also be attenuated by phentolamine (i.v.), but not by propranolol or methyl atropine. These results indicate that the INS-pressor response is mediated by RVL (alpha-, beta- and M-receptors) -sympathetic vasoconstrictor nerve system.