Chen H, Zhu H, Tang C
Division of Cardiology, Affiliated Hospital of Xuzhou Medical College.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):346-8.
In this study, we have observed the effect of L-arginine(L-arg) and omega N-nitro-L-arginine (LNNA) on the contractile-relaxation response and the cGMP level in arterial strip using the model of rat thoracic aorta with endothelial injury and neointimal formation. Organ chamber experiment and radioimmunoassay showed that, the 3rd day after endothelial injury of the rat thoracic aorta, their endothelium-dependent relaxtion response caused by L-arg, as well as endothelium dependent contractile response caused by LNNA were impaired seriously, basic cGMP reduced obviously, and the change of cGMP caused by L-Arg and LNNA was impaired markedly. On the 10th day after injury a pronounced recovery was noticed, and 21st day, the situation was further improved, but could not restore completely. The results indicate that the production of EDRF in the rat thoracic aorta after endothelial injury may be impaired seriously, and could not recover completely for a longer time.
在本研究中，我们利用大鼠胸主动脉内皮损伤和新生内膜形成模型，观察了L-精氨酸（L-arg）和ω-N-硝基-L-精氨酸（LNNA）对动脉条收缩-舒张反应及cGMP水平的影响。器官浴槽实验和放射免疫测定显示，大鼠胸主动脉内皮损伤后第3天，L-arg引起的内皮依赖性舒张反应以及LNNA引起的内皮依赖性收缩反应严重受损，基础cGMP明显降低，L-精氨酸和LNNA引起的cGMP变化也明显受损。损伤后第10天出现明显恢复，第21天情况进一步改善，但仍不能完全恢复。结果表明，大鼠胸主动脉内皮损伤后内皮舒张因子的产生可能严重受损，且较长时间内不能完全恢复。
