荷包牡丹碱刺激大鼠垂体前叶四分体释放促肾上腺皮质激素（ACTH）

[Bicuculline stimulates the release of adrenocorticotropin (ACTH) from rat anterior pituitary quarters].

作者信息

Jiao K, Zhu Y, Zhang W, Wang F

机构信息

Department of Physiology, Fourth Military Medical University, Xian.

出版信息

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):349-51.

PMID:10322969

Abstract

The effect of gama-aminobutyric acid (GABA) on release of adrenocorticotropin (ACTH) from anterior pituitary quarters of male SD rats adrenalectomized for 96 hrs was investigated using the perfusion technique in vitro. Application of bicuculline (10(-6)mol/L), a specific GABA-A antagonist, resulted in a significant release of ACTH from perfused anterior pituitary quarters. But the same concentration of bicuculline had no effect on the release of ACTH from dispersed anterior cells of ADX rats in vitro. Taken together, these results suggest that GABA may play an important inhibitory role on ACTH secretion from pituitary in adrenalectomized rats.

摘要

采用体外灌流技术，研究了γ-氨基丁酸（GABA）对切除肾上腺96小时的雄性SD大鼠垂体前叶促肾上腺皮质激素（ACTH）释放的影响。应用特异性GABA-A拮抗剂荷包牡丹碱（10^(-6)mol/L）可导致灌流的垂体前叶显著释放ACTH。但相同浓度的荷包牡丹碱对体外培养的去肾上腺（ADX）大鼠分散的垂体前叶细胞释放ACTH没有影响。综上所述，这些结果表明，GABA可能对去肾上腺大鼠垂体ACTH的分泌起重要的抑制作用。