Samson W K, Murphy T, Schell D A
Department of Physiology, University of North Dakota School of Medicine, Grand Forks 58202-9037, USA.
Endocrinology. 1995 May;136(5):2349-52. doi: 10.1210/endo.136.5.7720684.
The potent hypotensive peptide, adrenomedullin (AdM), originally isolated from a human pheochromocytoma is present in a variety of rat and human tissues. We examined its potential effects in anterior pituitary gland, reasoning that it may be a feedback regulator of adrenocorticotropin (ACTH) secretion. Rat AdM11-50 inhibited basal ACTH secretion from dispersed, rat anterior pituitary cells in a significant, dose-related fashion (maximum inhibition at 10(-9) M). Rat AdM11-50 also inhibited, in a dose-related fashion, corticotropin releasing hormone (CRH)-stimulated ACTH secretion, but did not block the ability of CRH to stimulate cAMP accumulation in these cells. These findings suggest that in addition to peripheral actions in the vasculature and kidney, adrenomedullin may act within the anterior pituitary gland to control fluid and electrolyte homeostasis.
强效降压肽肾上腺髓质素（AdM）最初是从人嗜铬细胞瘤中分离出来的，存在于多种大鼠和人类组织中。我们研究了它在前垂体中的潜在作用，推断它可能是促肾上腺皮质激素（ACTH）分泌的反馈调节因子。大鼠AdM11 - 50以显著的剂量相关方式抑制分散的大鼠前垂体细胞的基础ACTH分泌（在10^(-9) M时最大抑制）。大鼠AdM11 - 50还以剂量相关方式抑制促肾上腺皮质激素释放激素（CRH）刺激的ACTH分泌，但不阻断CRH刺激这些细胞中cAMP积累的能力。这些发现表明，除了在血管系统和肾脏中的外周作用外，肾上腺髓质素可能在前垂体中发挥作用以控制体液和电解质平衡。
