Li L
Department of Forensic Medicine, Kunming Medical College, Yannan.
Fa Yi Xue Za Zhi. 1997;13(2):65-7, 76, 128.
This study used HPLC to detect the concentration of morphine in cardiac blood of rats treated with intramuscular injection of therapeutic and toxic dose morphine. The results showed, in the group with therapeutic dose morphine, the cardiac blood concentration of morphine increased significantly within 96 h after death (P < 0.01), these increase of the cardiac blood morphine correlated well with time. In the group with toxic dose morphine, the cardiac blood concentration of morphine did not change obviously within 12 h after death, but increased gradually 24 h, 48 h, 96 h after death (P < 0.01), however, the morphine changes intensity is not more significant than the therapeutic dose. This study proved that the dose of morphine injected antemortem affects directly the postmortem cardiac blood morphine levels. It is analysed for the possible mechanism of the change.
本研究采用高效液相色谱法检测肌肉注射治疗剂量和中毒剂量吗啡的大鼠心脏血液中吗啡的浓度。结果显示，在治疗剂量吗啡组，死亡后96小时内心脏血液中吗啡浓度显著升高（P<0.01），心脏血液中吗啡的升高与时间密切相关。在中毒剂量吗啡组，死亡后12小时内心脏血液中吗啡浓度无明显变化，但在死亡后24小时、48小时、96小时逐渐升高（P<0.01），然而，吗啡变化强度不如治疗剂量组显著。本研究证明生前注射吗啡的剂量直接影响死后心脏血液中吗啡水平，并对其变化的可能机制进行了分析。
