• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

L-threo-3,4-dihydroxyphenylserine enhances the orthostatic responses of plasma renin activity and angiotensin II in multiple system atrophy.

作者信息

Yoshizawa T, Fujita T, Mizusawa H, Shoji S

机构信息

Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Japan.

出版信息

J Neurol. 1999 Mar;246(3):193-7. doi: 10.1007/s004150050333.

DOI:10.1007/s004150050333
PMID:10323317
Abstract

We evaluated the effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on the response of blood pressure and vasoactive factors during head-up tilt in patients with multiple system atrophy (MSA). After the daily oral administration of 300 mg L-threo-DOPS for 2 weeks we observed a significant reduction in the decline of systolic blood pressure during 60 degrees head-up-tilt. In concordance with this result, we detected significant increases in postural changes in plasma renin activity and angiotensin II following L-threo-DOPS treatment. The enhanced responses of these vasoactive mediators by L-threo-DOPS during head-up tilt may contribute to the improvement in orthostatic hypotension in patients with MSA.

摘要

相似文献

1
L-threo-3,4-dihydroxyphenylserine enhances the orthostatic responses of plasma renin activity and angiotensin II in multiple system atrophy.
J Neurol. 1999 Mar;246(3):193-7. doi: 10.1007/s004150050333.
2
L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure.L-苏糖型二羟基苯丝氨酸（L-苏糖型-DOPS；屈昔多巴）用于治疗神经源性直立性低血压：一项针对多系统萎缩和单纯自主神经功能衰竭的多国、多中心、剂量范围研究。
Clin Auton Res. 2001 Aug;11(4):235-42. doi: 10.1007/BF02298955.
3
[Effects of L-threo-Dops on orthostatic hypotension in Parkinson's disease].[L-苏糖酸多巴胺对帕金森病直立性低血压的影响]
No To Shinkei. 1998 Feb;50(2):157-63.
4
Effect of L-threo-3,4-dihydroxyphenylserine on muscle sympathetic nerve activity in humans.L-苏糖型-3,4-二羟基苯丝氨酸对人体肌肉交感神经活动的影响。
J Auton Nerv Syst. 1992 Jun 15;39(2):159-67. doi: 10.1016/0165-1838(92)90056-m.
5
Treatment of orthostatic hypotension in Shy-Drager syndrome with DL-threo-3,4-dihydroxyphenylserine: a case report.
Eur Neurol. 1985;24(5):330-4. doi: 10.1159/000115820.
6
Improved orthostatic tolerance in familial amyloidotic polyneuropathy with unnatural noradrenaline precursor L-threo-3,4-dihydroxyphenylserine.使用非天然去甲肾上腺素前体L-苏式-3,4-二羟基苯丝氨酸改善家族性淀粉样多神经病患者的直立耐受能力。
J Auton Nerv Syst. 1997 Jan 12;62(1-2):63-71. doi: 10.1016/s0165-1838(96)00110-5.
7
d,l-threo-3,4-dihydroxyphenylserine restores sympathetic control and cures orthostatic hypotension in dopamine beta-hydroxylase deficiency.d，l-苏式-3,4-二羟基苯丝氨酸可恢复多巴胺β-羟化酶缺乏症患者的交感神经控制并治愈体位性低血压。
J Hypertens Suppl. 1988 Dec;6(4):S547-9. doi: 10.1097/00004872-198812040-00172.
8
The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial.3,4-DL-苏式二羟基苯丝氨酸治疗神经源性直立性低血压：一项随机、安慰剂对照、交叉试验。
Neurology. 1999 Dec 10;53(9):2151-7. doi: 10.1212/wnl.53.9.2151.
9
Clinical effects of L-threo-3,4-dihydroxyphenylserine on orthostatic hypotension in hemodialysis patients.
Nephron. 2002 Apr;90(4):384-90. doi: 10.1159/000054725.
10
Studies of neurocirculatory effects of long-term L-threo-3,4-dihydroxyphenylserine administration in a patient with familial amyloidotic polyneuropathy.长期给予L-苏型-3,4-二羟基苯丝氨酸对一名家族性淀粉样多神经病患者神经循环影响的研究。
Acta Neurol Scand. 1988 May;77(5):409-13. doi: 10.1111/j.1600-0404.1988.tb05927.x.