Kothari S S, Balijepally S, Taneja K
Department of Cardiology, All India Institute of Medical Sciences, New Delhi.
Cardiol Young. 1999 Mar;9(2):194-6. doi: 10.1017/s1047951100008441.
We report amiodarone-induced pulmonary toxicity in an 18-year-old boy who had undergone corrective surgery for tetralogy of Fallot 4 years earlier, and was treated with amiodarone because of recurrent malignant postoperative ventricular tachyarrhythmias. Toxicity was recognized on the basis of clinical features, chest X-ray, high-resolution contrast enhanced computerized tomography, and resolution of the findings subsequent to withdrawal of amiodarone and treatment with steroids. Pulmonary toxicity due to amiodarone, as far as we know, has not been reported in children and young adults, and its occurence even in young adults requires wider appreciation.
我们报告了一名18岁男孩发生胺碘酮所致的肺毒性。该男孩4年前接受了法洛四联症矫正手术,因术后反复出现恶性室性快速心律失常而接受胺碘酮治疗。根据临床特征、胸部X线、高分辨率对比增强计算机断层扫描以及在停用胺碘酮并使用类固醇治疗后相关表现的消退情况,确认了毒性反应。据我们所知,胺碘酮所致的肺毒性在儿童和年轻成人中尚未见报道,即便在年轻成人中发生也需要更广泛的认识。