Catholic University of Sacred Heart, Rome, Italy.
Department of Cardiovascular & Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Future Cardiol. 2021 Sep;17(6):991-997. doi: 10.2217/fca-2020-0168. Epub 2020 Dec 17.
Amiodarone is a drug commonly used to treat and prevent cardiac arrhythmias, but it is often associated with several adverse effects, the most serious of which is pulmonary toxicity. A 79-year-old man presented with respiratory failure due to interstitial pneumonia during the COVID-19 pandemic. The viral etiology was nevertheless excluded by repeated nasopharyngeal swabs and serological tests and the final diagnosis was amiodarone-induced organizing pneumonia. The clinical and computed tomography findings improved after amiodarone interruption and steroid therapy. Even during a pandemic, differential diagnosis should always be considered and pulmonary toxicity has to be taken into account in any patient taking amiodarone and who has new respiratory symptoms.
胺碘酮是一种常用于治疗和预防心律失常的药物，但它常伴有多种不良反应，其中最严重的是肺毒性。在 COVID-19 大流行期间，一名 79 岁男性因间质性肺炎导致呼吸衰竭。然而，通过反复鼻咽拭子和血清学检查排除了病毒病因，最终诊断为胺碘酮诱导的机化性肺炎。停用胺碘酮和类固醇治疗后，临床和计算机断层扫描结果有所改善。即使在大流行期间，也应始终考虑鉴别诊断，对于任何服用胺碘酮且出现新的呼吸道症状的患者，都必须考虑肺毒性。
