0.1%阿达帕林与0.05%维甲酸治疗面部痤疮的半脸临床及生物仪器比较
Split-face clinical and bio-instrumental comparison of 0.1% adapalene and 0.05% tretinoin in facial acne.
作者信息
Piérard-Franchimont C, Henry F, Fraiture A L, Fumal I, Piérard G E
机构信息
Belgian SSTC Research Center 5596, Department of Dermatopathology, University Medical Center Sart-Tilman, Liège, Belgium.
出版信息
Dermatology. 1999;198(2):218-22. doi: 10.1159/000018117.
BACKGROUND
Adapalene and tretinoin are topical compounds active for treating acne.
OBJECTIVE
To compare the efficacity and safety of adapalene 0.1% gel and tretinoin 0.05% gel in moderately severe facial acne using clinical and objective biometrological assessments. Such information is currently lacking in the literature.
METHODS
The split-face method was used in 25 acne volunteers for a 6-week treatment. In addition to clinical counts of lesions, the amount of comedones was assessed using computer-assisted morphometry of cyanoacrylate follicular biopsies. The erythema index and squamometry values were used to quantitate skin irritation.
RESULTS
The tretinoin formulation brought better comedolysis and clinical improvement than the adapalene formulation. Erythema was transiently more pronounced on the tretinoin-treated side. Squamometry yielded no significant difference between both products.
CONCLUSION
Tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, although with temperate tolerability.
背景
阿达帕林和维甲酸是治疗痤疮的外用活性化合物。
目的
通过临床和客观生物计量学评估，比较0.1%阿达帕林凝胶和0.05%维甲酸凝胶治疗中度重度面部痤疮的疗效和安全性。目前文献中缺乏此类信息。
方法
采用半脸法对25名痤疮志愿者进行为期6周的治疗。除了对皮损进行临床计数外，还使用氰基丙烯酸酯毛囊活检的计算机辅助形态测量法评估粉刺数量。使用红斑指数和鳞屑测量值来量化皮肤刺激。
结果
维甲酸制剂比阿达帕林制剂带来更好的粉刺溶解和临床改善。在维甲酸治疗的一侧，红斑暂时更明显。两种产品之间的鳞屑测量没有显著差异。
结论
0.05%维甲酸凝胶比0.1%阿达帕林凝胶具有更强的抗痤疮疗效，尽管耐受性一般。
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