Zhang X, Xie T, Zhang Z, Yan X
Department of Experimental Pathology, Hebei Medical University, Shijiazhuang, China.
Wei Sheng Yan Jiu. 1997 Mar;26(2):110-2, 116.
Effects of Sterigmatocystin (ST) on ras p21 expression and ultrastructure of human lung fibroblasts in vitro were studied with immunological flow cytometry and electron microscopy. The results showed that ras p21 expression in the ST treated cells was dramatically increased and the ultrastructural features of malignant cells, such as enlarged nuclei with bizzar nuclear membranne folds and predominant nucleoli, could be seen.
采用免疫荧光流式细胞术和电子显微镜技术，研究了柄曲霉素（ST）对体外培养的人肺成纤维细胞ras p21表达及超微结构的影响。结果显示，经ST处理的细胞中ras p21表达显著增加，且可见到恶性细胞的超微结构特征，如细胞核增大、核膜出现奇异褶皱以及核仁占优势。
