接受地塞米松治疗慢性肺病的早产儿对加速接种b型流感嗜血杆菌疫苗的抗体反应。
Antibody response to accelerated Hib immunisation in preterm infants receiving dexamethasone for chronic lung disease.
作者信息
Robinson M J, Campbell F, Powell P, Sims D, Thornton C
机构信息
Neonatal Department, Hope Hospital, Salford.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1999 Jan;80(1):F69-71. doi: 10.1136/fn.80.1.f69.
Abstract
AIM
To study the effect of dexamethasone on the routine immunisation of preterm infants with chronic lung disease.
METHODS
Serum samples were obtained before and after immunisation from an unselected cohort of 59 preterm infants. Haemophilus influenzae antibodies were measured using an ELISA method and differences in the geometric mean values between the two groups of babies analysed.
RESULTS
Sixteen infants received no dexamethasone. Before and after immunisation antibody titres for those receiving no dexamethasone were 0.16 and 4.63 mcg IgG/ml. Corresponding values for those receiving dexamethasone were 0.10 and 0.51 mcg IgG/ml, respectively.
CONCLUSION
Dexamethasone used in the treatment of chronic lung disease seems to significantly affect the antibody response of preterm infants to immunisation against Haemophilus influenzae.
摘要
目的
研究地塞米松对患有慢性肺病的早产儿常规免疫的影响。
方法
从59名未经过挑选的早产儿队列中获取免疫前后的血清样本。采用酶联免疫吸附测定法测量流感嗜血杆菌抗体，并分析两组婴儿几何平均值的差异。
结果
16名婴儿未接受地塞米松治疗。未接受地塞米松治疗的婴儿免疫前后抗体滴度分别为0.16和4.63微克IgG/毫升。接受地塞米松治疗的婴儿相应值分别为0.10和0.51微克IgG/毫升。
结论
用于治疗慢性肺病的地塞米松似乎会显著影响早产儿对流感嗜血杆菌免疫的抗体反应。
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本文引用的文献
1
Combined diphtheria, tetanus, pertussis, and Haemophilus influenzae type b vaccines for primary immunisation.用于初次免疫的白喉、破伤风、百日咳和b型流感嗜血杆菌联合疫苗。
Arch Dis Child. 1996 Oct;75(4):298-303. doi: 10.1136/adc.75.4.298.
2
Changing patterns of invasive Haemophilus influenzae disease in England and Wales after introduction of the Hib vaccination programme.在引入b型流感嗜血杆菌疫苗接种计划后，英格兰和威尔士侵袭性流感嗜血杆菌疾病模式的变化。
BMJ. 1996 Jan 20;312(7024):160-1. doi: 10.1136/bmj.312.7024.160.
3
Response to Haemophilus influenzae type b conjugate vaccine in chronically ill premature infants.慢性疾病早产婴儿对b型流感嗜血杆菌结合疫苗的反应。
J Pediatr. 1993 Nov;123(5):791-4. doi: 10.1016/s0022-3476(05)80862-5.
4
Antibody response to accelerated immunisation with diphtheria, tetanus, pertussis vaccine.
Lancet. 1993 Jul 24;342(8865):203-5. doi: 10.1016/0140-6736(93)92298-8.
5
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.下丘脑-垂体-肾上腺轴与免疫介导的炎症。
N Engl J Med. 1995 May 18;332(20):1351-62. doi: 10.1056/NEJM199505183322008.
6
Immunologic response of extremely premature infants to tetanus, Haemophilus influenzae, and polio immunizations.
Pediatrics. 1995 Jul;96(1 Pt 1):18-22.
7
Prevention of Hemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine.用b型流感嗜血杆菌荚膜多糖疫苗预防b型流感嗜血杆菌菌血症感染。
N Engl J Med. 1984 Jun 14;310(24):1561-6. doi: 10.1056/NEJM198406143102404.
8
The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b.针对b型流感嗜血杆菌荚膜多糖的血清抗体保护水平。
J Infect Dis. 1983 Jun;147(6):1100. doi: 10.1093/infdis/147.6.1100.
9
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Pediatrics. 1984 Jan;73(1):37-42.
10
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J Pediatr. 1989 Jan;114(1):97-100. doi: 10.1016/s0022-3476(89)80611-0.
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