Levy Y, Glovinsky Y
Department of Ophthalmology, Assaf Harofeh Medical Center, Tel Aviv University, Israel.
Eye (Lond). 1998;12 ( Pt 6):967-9. doi: 10.1038/eye.1998.250.
In view of research demonstrating the ability of anthocyanosides in a single oral dose to improve night vision in normal individuals, it was decided to evaluate their effect on three night vision tests: full-field scotopic retinal threshold (SRT), dark adaptation rate (DAR) and mesopic contrast sensitivity (MCS).
In a double-masked, placebo-controlled, cross-over study, 16 young normal volunteers were randomly assigned to one of four different regimens of single oral administrations of 12, 24 and 36 mg of anthocyanosides, and a placebo, with a 2 week washout period between doses. SRT, DAR and MCS were measured immediately before, and 4, 8 and 24 h after treatment.
No significant effect was found on any of the three night vision tests during the 24 h following a single oral administration of 12, 24 or 36 mg anthocyanosides. The study had a power of 0.95 to detect a 0.1 log unit improvement in SRT and 0.5 log unit improvement in MCS.
Single oral administration of 12-36 mg of anthocyanosides appears to lack significant effect on militarily relevant night vision tests.
鉴于有研究表明单次口服花青素苷能够改善正常人的夜间视力，因此决定评估其对三项夜间视力测试的影响：全视野暗视视网膜阈值（SRT）、暗适应率（DAR）和中间视觉对比敏感度（MCS）。
在一项双盲、安慰剂对照、交叉研究中，16名年轻正常志愿者被随机分配到单次口服12毫克、24毫克和36毫克花青素苷及安慰剂这四种不同给药方案中的一种，两次给药之间有2周的洗脱期。在治疗前以及治疗后4小时、8小时和24小时测量SRT、DAR和MCS。
单次口服12毫克、24毫克或36毫克花青素苷后的24小时内，未发现对三项夜间视力测试中的任何一项有显著影响。该研究有95%的把握度检测到SRT改善0.1对数单位以及MCS改善0.5对数单位。
单次口服12 - 36毫克花青素苷似乎对与军事相关的夜间视力测试没有显著影响。
