van Echten J, Timmer B, Dam A, Sleijfer D T, Schraffordt Koops H, de Jong B
Department of Medical Genetics, University of Groningen, The Netherlands.
Cancer Genet Cytogenet. 1999 May;111(1):49-54. doi: 10.1016/s0165-4608(98)00211-8.
We report on the cytogenetics of a primary testicular nonseminoma, a residual mature teratoma after remission-induction chemotherapy, and a late relapse after 9 years of follow-up, in one patient. The late relapse was composed of a mature teratoma and a yolk sac tumor component. Cytogenetic comparison of the different tumors shows that progression of primary testicular nonseminoma to residual mature teratoma and to a late-relapse lesion is accompanied by net loss of chromosomes. In addition, our findings may suggest that transformation to viable cancer in a late-relapse lesion is accompanied by further chromosomal losses.
我们报告了一名患者原发性睾丸非精原细胞瘤、缓解诱导化疗后的残留成熟畸胎瘤以及随访9年后的晚期复发肿瘤的细胞遗传学情况。晚期复发肿瘤由成熟畸胎瘤和卵黄囊瘤成分组成。对不同肿瘤进行细胞遗传学比较显示，原发性睾丸非精原细胞瘤进展为残留成熟畸胎瘤以及晚期复发病变伴随着染色体的净丢失。此外，我们的研究结果可能表明，晚期复发病变向可存活癌症的转变伴随着进一步的染色体丢失。
