Castedo S M, Oosterhuis J W, de Jong B, Seruca R, Dam A, Buist J, Schraffordt Koops H, Sleijfer D T
Department of Human Genetics, University of Groningen, The Netherlands.
Cancer Genet Cytogenet. 1988 May;32(1):51-7. doi: 10.1016/0165-4608(88)90311-1.
We have been able to study the karyotypes and measure the DNA content in both the primary nonseminomatous germ cell tumor of the testes and the residual mature teratoma after chemotherapy of the same patient. Based on these and other studies, the mechanism of therapy-related differentiation in germ cell tumors of the testes is discussed.
我们已经能够对同一患者的原发性睾丸非精原细胞瘤和化疗后的残余成熟畸胎瘤进行核型研究并测量DNA含量。基于这些研究及其他研究,本文讨论了睾丸生殖细胞肿瘤中与治疗相关的分化机制。