Nakaguchi H, Fujimaki T, Matsuno A, Matsuura R, Asai A, Suzuki I, Sasaki T, Kirino T
Department of Neurosurgery, The University of Tokyo Hospital, Japan.
Cancer. 1999 May 15;85(10):2249-54.
Meningiomas are benign tumors that can be cured by surgical removal. However, tumors located deeply within or close to vital structures cannot be removed completely and require repeated surgery. This study was designed to clarify whether immunohistochemical study using MIB-1 monoclonal antibody is useful for determining the rate of regrowth for this tumor.
Tumor volume doubling time (Td) was measured by using computed tomography or magnetic resonance imaging neuroimages during 29 different follow-up periods after surgery. MIB-1 monoclonal antibody was used to stain Ki-67 proliferating cell antigen in surgical specimens, and the MIB-1 staining index (SI) was determined independently of neuroimaging analysis. These two values and other clinical parameters were analyzed statistically.
The Td values varied from 19-6830 days (median, 350 days); the Td values were <365 days in 15 cases, 365-730 days in 8 cases, and >730 days in 6 cases. There was no significant correlation between age and Td value, but all 6 patients whose Td values were >2 years were age >50. There was a strong inverse correlation between log(Td) and MIB-1 SI (P < 0.001). In three cases, more than three surgical procedures were performed for tumor recurrence. The MIB-1 values did not increase at the time of the first recurrence but increased at later recurrences. The calculated Td values also were not shortened until the second recurrence.
Using the MIB-1 SI makes it possible to predict the regrowth potential of a tumor after initial surgery.
脑膜瘤是良性肿瘤，可通过手术切除治愈。然而，位于重要结构深部或附近的肿瘤无法完全切除，需要反复手术。本研究旨在阐明使用MIB-1单克隆抗体进行免疫组织化学研究是否有助于确定该肿瘤的复发率。
在术后29个不同的随访期内，使用计算机断层扫描或磁共振成像神经影像测量肿瘤体积倍增时间（Td）。使用MIB-1单克隆抗体对手术标本中的Ki-67增殖细胞抗原进行染色，独立于神经影像分析确定MIB-1染色指数（SI）。对这两个值和其他临床参数进行统计学分析。
Td值在19 - 6830天之间（中位数为350天）；15例Td值<365天，8例Td值在365 - 730天之间，6例Td值>730天。年龄与Td值之间无显著相关性，但Td值>2年的所有6例患者年龄均>50岁。log(Td)与MIB-1 SI之间存在强烈的负相关（P < 0.001）。3例患者因肿瘤复发接受了3次以上手术。MIB-1值在首次复发时未增加，但在随后的复发中增加。计算得出的Td值直到第二次复发时才缩短。
使用MIB-1 SI能够预测初次手术后肿瘤的复发潜能。
