Miyagami M, Shibuya T, Miyagi A, Tsubokawa T
Department of Neurological Surgery, School of Medicine Nihon University, Tokyo, Japan.
No To Shinkei. 1996 Jan;48(1):39-43.
Tumor recurrence was observed in 12 (11.3%) out of 106 cases of intracranial meningioma followed for more than 5 years. Proliferative potential was evaluated immunohistochemically with MIB-1 monoclonal antibodies in 37 cases of non-recurrent meningioma and 12 cases (21 samples) of recurrent meningioma. The proliferating cell index (PCI) was much higher in the non-recurrent meningiomas than the recurrent meningiomas (10.6 +/- 7.7 [mean +/- SD] versus 1.9 +/- 1.5). Most recurrent meningiomas had high PCI values, greater than 3%. High PCI values of more than 5% were found in 13 (62%) of the 21 samples of recurrent meningioma. However, only 4 of the 37 cases of nonrecurrent meningioma had high PCI values with MIB-1 of more than 3%. The 12 cases of recurrent meningioma were classified into 3 groups: 6 cases in which both the initial and recurrent meningiomas were benign (Group I), 5 cases in which the meningioma at the time of the initial operation was benign, but the recurrent meningioma was malignant (Group II), and one case in which malignant meningioma was diagnosed at the time of the initial operation (Group III). The PCI values with MIB-1 in most of the recurrent meningiomas were higher at the time of recurrence than at the time of the initial operation. Malignant meningiomas, such as anaplastic and atypical meningioma, and some meningotheliomatous meningiomas among the benign meningiomas recurred and had higher PCI with MIB-1 values than other meningiomas. It is concluded that PCI with MIB-1 is important as a predictive factor for the recurrence of meningiomas. Meningiomas having a PCI value with MIB-1 of more than 3% in particular should be followed carefully.
在106例随访超过5年的颅内脑膜瘤病例中，观察到12例（11.3%）出现肿瘤复发。对37例非复发性脑膜瘤和12例（21个样本）复发性脑膜瘤进行MIB-1单克隆抗体免疫组化评估增殖潜能。非复发性脑膜瘤的增殖细胞指数（PCI）远高于复发性脑膜瘤（10.6±7.7[平均值±标准差]对1.9±1.5）。大多数复发性脑膜瘤的PCI值较高，大于3%。在21个复发性脑膜瘤样本中，13个（62%）的PCI值高于5%。然而，37例非复发性脑膜瘤中只有4例的MIB-1 PCI值高于3%。12例复发性脑膜瘤分为3组：6例初次和复发性脑膜瘤均为良性（I组），5例初次手术时脑膜瘤为良性，但复发性脑膜瘤为恶性（II组），1例初次手术时诊断为恶性脑膜瘤（III组）。大多数复发性脑膜瘤复发时的MIB-1 PCI值高于初次手术时。恶性脑膜瘤，如间变性和非典型脑膜瘤，以及一些良性脑膜瘤中的脑膜皮型脑膜瘤会复发，且其MIB-1值的PCI高于其他脑膜瘤。结论是，MIB-1的PCI作为脑膜瘤复发的预测因素很重要。特别是MIB-1的PCI值超过3%的脑膜瘤应仔细随访。
