Dimeo F C, Stieglitz R D, Novelli-Fischer U, Fetscher S, Keul J
Department of Rehabilitation, Prevention and Sports Medicine, Freiburg University Medical Center, Germany.
Cancer. 1999 May 15;85(10):2273-7.
Fatigue is a common and often severe problem in cancer patients undergoing chemotherapy. The authors postulated that physical activity training can reduce the intensity of fatigue in this group of patients.
A group of cancer patients receiving high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (training group; n = 27) followed an exercise program during hospitalization. The program was comprised of biking on an ergometer in the supine position following an interval training pattern for 30 minutes daily. Patients in the control group (n = 32) did not train. Psychologic distress was assessed at hospital admission and discharge with the Profile of Mood States and Symptom Check List 90.
By the time of hospital discharge, fatigue and somatic complaints had increased significantly in the control group (P for both < 0.01) but not in the training group. Furthermore, by the time of hospital discharge, the training group had a significant improvement in several scores of psychologic distress (obsessive-compulsive traits, fear, interpersonal sensitivity, and phobic anxiety) (P value for all scores < 0.05); this outcome was not observed in the control group.
The current study found that aerobic exercise can reduce fatigue and improve psychologic distress in cancer patients undergoing chemotherapy.
疲劳是接受化疗的癌症患者中常见且往往较为严重的问题。作者推测体育活动训练可以降低该组患者的疲劳强度。
一组接受高剂量化疗后进行自体外周血干细胞移植的癌症患者（训练组；n = 27）在住院期间遵循一项运动计划。该计划包括每天以间歇训练模式在仰卧位的测力计上骑行30分钟。对照组（n = 32）的患者不进行训练。在入院和出院时使用情绪状态剖面图和症状自评量表90评估心理困扰。
到出院时，对照组的疲劳和躯体不适显著增加（两者P值均<0.01），而训练组没有。此外，到出院时，训练组在几个心理困扰评分（强迫性特质、恐惧、人际敏感性和恐惧焦虑）方面有显著改善（所有评分的P值<0.05）；对照组未观察到这一结果。
当前研究发现有氧运动可以减轻接受化疗的癌症患者的疲劳并改善心理困扰。
