Dimeo F C, Tilmann M H, Bertz H, Kanz L, Mertelsmann R, Keul J
Department of Rehabilitation, Prevention and Sports Medicine, Freiburg University Medical Center, Germany.
Cancer. 1997 May 1;79(9):1717-22.
Fatigue and loss of physical performance are frequent problems of cancer patients. In a pilot study, the authors evaluated the feasibility and effects of aerobic training in the rehabilitation of cancer patients after completing high dose chemotherapy.
Sixteen patients participated in a specially designed rehabilitation program for 6 weeks. The patients entered the program, which consisted of walking on a treadmill, shortly after completing treatment. Sixteen patients who did not train served as controls. Physical performance (maximum speed on the treadmill test), cardiac function, and hemoglobin concentration were compared at the time of discharge from the hospital and 7 weeks later. At the second examination, fatigue and limitations in daily activities due to impaired endurance were assessed during personal interviews.
At the time of discharge from the hospital, maximum physical performance (training group: 6.2 +/- 1.1 km/hour; controls: 6.2 +/- 1.3 km/hour) and hemoglobin concentration (training group: 10.1 +/- 1.4 g/dL; controls: 10.1 +/- 1.2 g/dL) were similar for both groups. After 7 weeks, improvement in maximum physical performance (training group: 8.3 +/- 1.6 km/hour; controls 7.5 +/- 1.3 km/hour) and hemoglobin concentration (training group: 13 +/- 1 g/dL controls: 12 +/- 1.4 g/dL) were significantly higher for the training group (P < 0.05). By the second examination, no patient in the training group but 4 controls (25%) reported fatigue and limitations in daily activities due to low physical performance.
Aerobic exercise improves the physical performance of cancer patients recovering from high dose chemotherapy. To reduce fatigue, this group of patients should be counseled to increase physical activity rather than rest after treatment.
疲劳和身体机能下降是癌症患者常见的问题。在一项初步研究中，作者评估了有氧运动训练对完成高剂量化疗后的癌症患者康复的可行性和效果。
16名患者参加了一项为期6周的专门设计的康复计划。患者在完成治疗后不久就开始参加该计划，内容包括在跑步机上行走。16名未接受训练的患者作为对照。在出院时和7周后比较了身体机能（跑步机测试的最大速度）、心脏功能和血红蛋白浓度。在第二次检查时，通过个人访谈评估了由于耐力受损导致的疲劳和日常活动受限情况。
出院时，两组的最大身体机能（训练组：6.2±1.1千米/小时；对照组：6.2±1.3千米/小时）和血红蛋白浓度（训练组：10.1±1.4克/分升；对照组：10.1±1.2克/分升）相似。7周后，训练组的最大身体机能（训练组：8.3±1.6千米/小时；对照组7.5±1.3千米/小时）和血红蛋白浓度（训练组：13±1克/分升；对照组：12±1.4克/分升）的改善明显更高（P<0.05）。到第二次检查时，训练组没有患者报告因身体机能低而出现疲劳和日常活动受限，但对照组有4名患者（25%）报告了此类情况。
有氧运动可改善从高剂量化疗中康复的癌症患者的身体机能。为了减轻疲劳，应该建议这类患者在治疗后增加身体活动而不是休息。
