Scrofani R, Cialfi A, Ravagnan S, Fundarò P
Divisione di Chirurgia Toracica e Cardiovascolare, Ospedale L. Sacco, Milano.
G Ital Cardiol. 1999 Apr;29(4):418-23.
Operative correction of chronic ischemic mitral regurgitation (CIMR) is associated with a high-risk approach. The objective of this retrospective study was to evaluate the short- and long-term results of surgical treatment of CIMR.
From 1989 to 1997, mitral valve replacement or repair was performed on 46 patients with CIMR. The average age range was 63.7 +/- 6.9; 8 patients were females; 30 patients (65.2%) were in New York Heart Association (NYHA) functional class III or IV; 4 patients (8.6%) were in chronic atrial fibrillation and preoperative myocardial infarction was lower in 23 patients (50%). Preoperative echo-Doppler analysis showed severe mitral insufficiency in 15 patients (32.6%). Preoperative mean pulmonary artery pressure (PAP) was 33.6 +/- 13.6 mmHg, mean ejection fraction (EF) 37.8 +/- 13.5%. Mitral valve replacement was performed in 12 patients (26%). Mitral valve repair was performed in 34 patients (73.9%). Myocardial revascularization was performed in 42 patients (91.3%) (mean graft/patient 2.2 +/- 0.8); aneurysmectomy was performed in 5 patients (10.8%), and in 2 patients (4.3%) tricuspid insufficiency was corrected by performing annuloplasty.
The overall operative mortality was 8.6% (4 patients). The operative mortality for repair was 5.8% (2 patients) and for replacement was 16.6% (2 patients). One patient was reoperated three days after first operation due to annuloplasty dehiscence. Postoperative morbidity included low output syndrome in 7 patients (15.2%), bleeding in 2 patients (4.3%), and cerebral embolism in 2 patients (4.3%). The mean length of stay in intensive care was 6.5 +/- 10.5 days. Follow-up (mean 27.6 +/- 3.3 months) was 88% complete and revealed good functional and clinical results: 86.4% of the patients in I-II NYHA class. One patient was reoperated due to mitral insufficiency progression. Two late deaths occurred, one due to acute myocardial infarction and the other to lung cancer.
While long-term follow-up is mandatory, our results suggest that: a) surgical treatment of CIMI is feasible with acceptable operative risks; b) mid-term functional and clinical results are favorable; c) the choice of treatment--valve replacement or repair--is still debatable.
慢性缺血性二尖瓣反流(CIMR)的手术矫正具有高风险。这项回顾性研究的目的是评估CIMR手术治疗的短期和长期结果。
1989年至1997年,对46例CIMR患者进行了二尖瓣置换或修复手术。平均年龄范围为63.7±6.9岁;8例为女性;30例(65.2%)处于纽约心脏协会(NYHA)心功能III或IV级;4例(8.6%)为慢性房颤,23例(50%)术前心肌梗死发生率较低。术前超声多普勒分析显示15例(32.6%)存在严重二尖瓣关闭不全。术前平均肺动脉压(PAP)为33.6±13.6 mmHg,平均射血分数(EF)为37.8±13.5%。12例(26%)患者进行了二尖瓣置换。34例(73.9%)患者进行了二尖瓣修复。42例(91.3%)患者进行了心肌血运重建(平均每位患者移植血管2.2±0.8支);5例(10.8%)患者进行了动脉瘤切除术,2例(4.3%)患者通过瓣环成形术纠正了三尖瓣关闭不全。
总体手术死亡率为8.6%(4例)。修复手术的死亡率为5.8%(2例),置换手术的死亡率为16.6%(2例)。1例患者在首次手术后3天因瓣环成形术裂开而再次手术。术后并发症包括7例(15.2%)低心排血量综合征、2例(4.3%)出血和2例(4.3%)脑栓塞。重症监护病房的平均住院时间为6.5±10.5天。随访(平均27.6±3.3个月)完成率为88%,显示出良好的功能和临床结果:86.4%的患者处于NYHA I-II级。1例患者因二尖瓣反流进展而再次手术。发生2例晚期死亡,1例死于急性心肌梗死,另1例死于肺癌。
虽然长期随访是必要的,但我们的结果表明:a)CIMI的手术治疗在可接受的手术风险下是可行的;b)中期功能和临床结果良好;c)治疗方式的选择——瓣膜置换或修复——仍存在争议。