Mijatov M, Jonjev Z, Konstantinović Z, Golubović M, Radovanović N
Institut za kardiovaskularne bolesti Univerzitetska klinika za kardiovaskularnu hirurgiju, Sremska Kamenica.
Med Pregl. 2000 Jan-Feb;53(1-2):68-73.
Ischemic mitral insufficiency is a clinical syndrome described as a consequence of the coronary artery disease where the basic problem is blood regurgitation between the left ventricle and left atrium following mitral annulus dilatation. Mitral regurgitation occurs in different degrees during the natural evolution of the ischemic heart disease. The main reason for the existence of mitral regurgitation is global deterioration in the left ventricle geometry as a consequence of myocardial infarction or/and left ventricle dilatation. Surgical correction of this problem is possible by simultaneous correction of mitral insufficiency (repair or replacement) and complete myocardial revascularisation.
Complete hemodynamic monitoring was followed by Swan-Ganz catheter including: central venous pressure, mean pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac output, cardiac index and pulmonary vascular resistance. All surgical procedures were performed in extracorporeal circulation (ECC) with membrane oxygenator using moderate systemic hypothermia and transseptal surgical approach to mitral valve. Hemodynamic parameters were followed before and after ECC, immediately after surgery and during the first 48 hours after operation in the intensive care unit. In 88 patients posterior semicircular annuloplasty by N. Radovanović was performed whereas in 13 patients mitral valve replacement was done.
There is a great, statistically significant hemodynamic improvement after the surgical procedure and during the continuous 48 hours monitoring in the intensive care unit no matter if mitral repair or replacement was done. No statistically significant difference was recorded between these two groups considering that the hemodynamic improvement is very similar.
Simultaneous surgical procedures, including myocardial revascularization, mitral and usually consecutive tricuspid insufficiency correction, are a very common surgical problem with higher operative risk than isolated coronary bypass procedures. In 88 cases where mitral reconstruction was possible, posterior semicircular reductive annuloplasty was performed. Thus mitral annulus area reduction is achieved preserving its physiologic shape and avoiding rigidity. Mitral valve replacement includes implantation of the latest generation of bileaflet valve prosthesis and operative technique that preserves subvalvular apparatus to maintain myocardial contractility as much as possible. This policy and also good immediate postoperative care, improve the hemodynamic status in both groups.
All hemodynamic parameters followed by ECC and 48 hours in the intensive care unit were significantly improved no matter whether mitral reconstruction or replacement was done. There is no statistically significant difference in hemodynamic parameters and clinical improvement between these two groups. Carefully chosen operative tactic and techniques as well as good preoperative and postoperative care may explain these very good results.
缺血性二尖瓣关闭不全是一种临床综合征,被描述为冠状动脉疾病的后果,其基本问题是二尖瓣环扩张后左心室与左心房之间的血液反流。在缺血性心脏病的自然演变过程中,二尖瓣反流会以不同程度出现。二尖瓣反流存在的主要原因是心肌梗死或/和左心室扩张导致左心室几何形状整体恶化。通过同时纠正二尖瓣关闭不全(修复或置换)和完全心肌血运重建,可以对这个问题进行手术矫正。
采用Swan - Ganz导管进行全面的血流动力学监测,包括:中心静脉压、平均肺动脉压、肺毛细血管楔压、心输出量、心脏指数和肺血管阻力。所有手术均在体外循环(ECC)下进行,使用膜式氧合器,采用中度全身低温及经房间隔手术入路处理二尖瓣。在ECC前后、手术刚结束后以及重症监护病房术后的头48小时内对血流动力学参数进行监测。88例患者采用N. Radovanović的后半圆瓣环成形术,13例患者进行二尖瓣置换术。
无论进行二尖瓣修复还是置换,手术后以及在重症监护病房连续48小时的监测期间,血流动力学均有显著改善,且具有统计学意义。考虑到血流动力学改善情况非常相似,两组之间未记录到统计学上的显著差异。
同时进行的手术,包括心肌血运重建、二尖瓣以及通常连续进行的三尖瓣关闭不全矫正,是一个非常常见的外科问题,其手术风险高于单纯的冠状动脉搭桥手术。在88例可行二尖瓣重建的病例中,进行了后半圆缩窄瓣环成形术。这样在保留二尖瓣环生理形状并避免僵硬的情况下实现了二尖瓣环面积的减小。二尖瓣置换包括植入最新一代的双叶瓣膜假体以及保留瓣下结构以尽可能维持心肌收缩力的手术技术。该策略以及良好的术后即时护理,改善了两组患者的血流动力学状态。
无论进行二尖瓣重建还是置换,ECC及重症监护病房48小时内监测的所有血流动力学参数均有显著改善。两组之间的血流动力学参数及临床改善情况无统计学显著差异。精心选择的手术策略和技术以及良好的术前和术后护理或许可以解释这些良好的结果。