Strauss M E, Andresko M, Stryker J C, Wardell J N
Am J Drug Alcohol Abuse. 1976;3(2):339-45. doi: 10.3109/00952997609077202.
Neonatal withdrawal is described for a sample of 70 infants born to addicted women treated with methadone and comprehensive prenatal care. Although symptoms were manifested by over 90% of the infants, those born to women receiving near-term average doses of less than or equal to 20 mg/day had significantly less symptomatology, weight loss, and need for pharmacologic treatment than those of mothers still on higher doses. Reduction of methadone dose levels during the last 6 weeks of pregnancy to less than or equal to 20 mg/day appears to reduce the severity of neonatal withdrawal.
对70名母亲为吸毒成瘾女性且接受美沙酮治疗及全面产前护理的婴儿样本进行了新生儿戒断情况描述。虽然超过90%的婴儿出现了症状，但母亲在孕期最后阶段接受近足月平均剂量小于或等于20毫克/天的婴儿，其症状、体重减轻及药物治疗需求均显著少于母亲仍服用较高剂量的婴儿。在妊娠最后6周将美沙酮剂量水平降至小于或等于20毫克/天，似乎可减轻新生儿戒断的严重程度。
