Vierimaa H, Sassi M L, Eloranta E, Rahiala M, Timisjärvi J, Saarela S, Risteli J
Department of Physiology, University of Oulu, Finland.
Comp Biochem Physiol B Biochem Mol Biol. 1999 Jan;122(1):111-7. doi: 10.1016/s0305-0491(98)10153-0.
Annual cycle of type I collagen formation and degradation and antler growth was studied in six adult female reindeer, Rangifer tarandus tarandus. Blood samples were collected twice a week during 1 year. Antler length was measured weekly during the antler growth period. An assay for human PICP, the carboxyterminal propeptide of type I procollagen, was used as an indicator of type I collagen formation and an assay for bovine ICTP, the carboxyterminal telopeptide of type I collagen, as an indicator of type I collagen degradation. PICP was clearly increased during the antler growth period. Also ICTP was slightly elevated during antler growth, but the highest values were found in autumn and winter. Our statistical analysis revealed that changes in lagged values (from 3 to 6 weeks) of PICP could be linked to the subsequent changes in the growth rate of the antler, although the highest values of PICP were found during the final third of antler growth. ICTP had significant predictive power as well, but the connection with the growth rate seemed more immediate than that of PICP. In conclusion, antler collagen synthesis can be predicted by PICP, but also ICTP was related to the antler growth.
在六只成年雌性驯鹿（Rangifer tarandus tarandus）中研究了I型胶原蛋白形成和降解的年度周期以及鹿茸生长情况。在一年中每周采集两次血样。在鹿茸生长期间每周测量鹿茸长度。使用针对人I型前胶原羧基末端前肽PICP的检测方法作为I型胶原蛋白形成的指标，以及针对牛I型胶原蛋白羧基末端端肽ICTP的检测方法作为I型胶原蛋白降解的指标。在鹿茸生长期间PICP明显增加。在鹿茸生长期间ICTP也略有升高，但在秋季和冬季发现其值最高。我们的统计分析表明，PICP滞后值（3至6周）的变化可能与鹿茸生长速率的后续变化相关，尽管PICP的最高值出现在鹿茸生长的最后三分之一阶段。ICTP也具有显著的预测能力，但其与生长速率的联系似乎比PICP更直接。总之，鹿茸胶原蛋白合成可以通过PICP预测，但ICTP也与鹿茸生长有关。
