Brown S T, Thompson S E, Biddle J W, Kraus S J, Zaidi A A, Kleris G S
Venereal Disease Control Division, Center for Prevention Services, Atlanta, Georgia 30333, USA.
Sex Transm Dis. 1982 Jan-Mar;9(1):9-14. doi: 10.1097/00007435-198201000-00002.
The efficacy of trimethoprim-sulfamethoxazole (TMP-SMZ; 80 mg of TMP and 400 mg of SMZ per tablet; nine tablets taken once daily for three days; total, 27 tablets) was compared with the U.S. Public Health Service recommended regimen of 2 g of tetracycline daily for five days for the treatment of uncomplicated genital gonorrhea. Fourteen (3%) of the 461 patients treated with tetracycline and 24 (5%) of the 477 patients treated with TMP-SMZ failed to be cured; the difference between the two groups was not significant. Treatment of patients with TMP-SMZ was more likely to fail if the isolates of Neisseria gonorrhoeae had MICs of > or = 0.5 microgram of TMP/ml and > or = 9.5 micrograms of SMZ/ml. Adverse effects were more often reported by patients receiving TMP-SMZ. The results show that TMP-SMZ is an effective therapy for uncomplicated gonococcal infections in men and women and may also eliminate agents causing postgonococcal urethritis. The utility of this drug combination may be limited by the adverse effects that are associated with the large dose used.
将甲氧苄啶-磺胺甲恶唑（TMP-SMZ；每片含80毫克TMP和400毫克SMZ；每日一次服用九片，共三天；总计27片）与美国公共卫生服务部推荐的治疗单纯性生殖器淋病的方案（每日2克四环素，连用五天）进行了疗效比较。在接受四环素治疗的461名患者中，有14名（3%）未治愈，在接受TMP-SMZ治疗的477名患者中，有24名（5%）未治愈；两组之间的差异不显著。如果淋病奈瑟菌分离株对TMP的最低抑菌浓度（MIC）≥0.5微克/毫升且对SMZ的MIC≥9.5微克/毫升，接受TMP-SMZ治疗的患者更有可能治疗失败。接受TMP-SMZ治疗的患者报告的不良反应更多。结果表明，TMP-SMZ是治疗男性和女性单纯性淋球菌感染的有效疗法，还可能消除引起淋菌性尿道炎后尿道炎的病原体。这种药物组合的效用可能会受到与大剂量使用相关的不良反应的限制。
