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Arsenic trioxide, a novel mitochondriotoxic anticancer agent?

作者信息

Kroemer G, de Thé H

出版信息

J Natl Cancer Inst. 1999 May 5;91(9):743-5. doi: 10.1093/jnci/91.9.743.

DOI:10.1093/jnci/91.9.743
PMID:10328097
Abstract
摘要

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Arsenic trioxide, a novel mitochondriotoxic anticancer agent?三氧化二砷，一种新型的线粒体毒性抗癌剂？
J Natl Cancer Inst. 1999 May 5;91(9):743-5. doi: 10.1093/jnci/91.9.743.
2
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6
JWA is required for arsenic trioxide induced apoptosis in HeLa and MCF-7 cells via reactive oxygen species and mitochondria linked signal pathway.通过活性氧和线粒体相关信号通路，三氧化二砷诱导HeLa和MCF-7细胞凋亡需要JWA。
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ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells.白藜芦醇和三氧化二砷诱导 A549 细胞凋亡的机制与 ROS 介导的内质网应激和线粒体功能障碍有关。
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8
Re: Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations.
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9
Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis.
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Arsenic-induced apoptosis in malignant cells in vitro.体外砷诱导恶性细胞凋亡。
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Sodium arsenite and arsenic trioxide differently affect the oxidative stress of lymphoblastoid cells: An intricate crosstalk between mitochondria, autophagy and cell death.亚砷酸钠和三氧化二砷对淋巴母细胞氧化应激的影响不同：线粒体、自噬和细胞死亡之间的复杂相互作用。
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PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation.多瘤病毒相关的核小体：组装与氧化应激敏感的小泛素样修饰蛋白化
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The roles of mitoferrin-2 in the process of arsenic trioxide-induced cell damage in human gliomas.线粒体铁转运蛋白2在三氧化二砷诱导人胶质瘤细胞损伤过程中的作用
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How animal models of leukaemias have already benefited patients.白血病动物模型如何已经使患者受益。
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Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.三氧化二砷下调特异性蛋白（Sp）转录因子，抑制膀胱癌细胞和肿瘤生长。
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Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin.三氧化二砷通过抑制核因子 κB 介导的 p73 转录抑制和防止 NF-κB 介导的 XIAP、cIAP2、BCL-XL 和 survivin 的诱导，上调 p73，诱导 NB-4，一种急性早幼粒细胞白血病细胞系，发生细胞凋亡。
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Arsenic trioxide exerts synergistic effects with cisplatin on non-small cell lung cancer cells via apoptosis induction.三氧化二砷通过诱导细胞凋亡与顺铂对非小细胞肺癌细胞产生协同作用。
J Exp Clin Cancer Res. 2009 Aug 8;28(1):110. doi: 10.1186/1756-9966-28-110.