Segal S, Ornoy A, Bercovici B, Antebi S O, Polishuk W Z
Br J Obstet Gynaecol. 1976 Feb;83(2):156-9. doi: 10.1111/j.1471-0528.1976.tb00799.x.
The histological appearances of 52 placentae from patients who had a urea-induced second trimester abortion were studied. Extensive subchorionic intervillous fibrin deposition and swollen degenerated stromal cells (probably Hofbauer cells), were found both in the placenta and membranes. Between urea injection and abortion, serial vaginal smears showed signs of progesterone deficiency. The urea-induced placental and fetal damage was similar to that seen with hypertonic saline.
对52例因尿素诱导而在孕中期流产患者的胎盘进行了组织学检查。在胎盘和胎膜中均发现广泛的绒毛膜下绒毛间纤维蛋白沉积以及肿胀变性的基质细胞（可能是霍夫鲍尔细胞）。在注射尿素至流产期间，连续的阴道涂片显示有孕酮缺乏的迹象。尿素诱导的胎盘和胎儿损伤与高渗盐水所致损伤相似。
