羊膜腔内注入尿素联合静脉滴注缩宫素用于孕中期引产。

Induction of midtrimester abortion with intra-amniotic urea and intravenous oxytocin.

作者信息

Smith W G, Allen H H, Collins J A, Roth J

出版信息

Am J Obstet Gynecol. 1977 Feb 1;127(3):228-31. doi: 10.1016/0002-9378(77)90458-6.

Abstract

Midtrimester abortions were induced in 295 patients with a combination of intra-amniotic urea and intravenous oxytocin. The mean injection-abortion interval was 26.4 hours. Abortion occurred spontaneously within 50 hours of amnioinfusion in 257 patients. The macerating effect of the hypertonic urea on fetal tissues allowed easy termination of the remaining 38 pregnancies by suction curettage at 50 hours after injection. Decreased urinary output occurred during the oxytocin infusions, but water intoxication was prevented by close monitoring of urinary output and serum electrolytes, and by the use of a concentrated solution of oxytocin in normal saline, allowing the administration of small volumes.

摘要

对295例患者采用羊膜腔内注射尿素和静脉滴注缩宫素相结合的方法进行中期引产。注射至流产的平均间隔时间为26.4小时。257例患者在羊膜腔灌注后50小时内自然流产。高渗尿素对胎儿组织的浸软作用使得在注射后50小时通过吸引刮宫术轻松终止了其余38例妊娠。静脉滴注缩宫素期间尿量减少，但通过密切监测尿量和血清电解质，并使用缩宫素生理盐水浓溶液以便小剂量给药，从而预防了水中毒。