Petitou M, Duchaussoy P, Driguez P A, Hérault J P, Lormeau J C, Herbert J M
Sanofi Recherche, Haemobiology Research Department, Toulouse, France.
Bioorg Med Chem Lett. 1999 Apr 19;9(8):1155-60. doi: 10.1016/s0960-894x(99)00155-9.
Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT III) binding pentasaccharide prolonged at the non-reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin.
已经获得了合成的十五糖、十七糖和十九糖，它们包含一个抗凝血酶III（AT III）结合五糖，该五糖在非还原端通过凝血酶结合域延长。十五糖是能够催化AT III抑制凝血酶的最短寡糖。十九糖是比标准肝素更有效的凝血酶抑制剂。
