Kulidjian A A, Inman R, Issekutz T B
Departments of Medicine and Immunology, University of Toronto and Toronto Western Hospital, Toronto, M5T 2S8, Canada.
Semin Immunol. 1999 Apr;11(2):85-93. doi: 10.1006/smim.1999.0164.
The ability of leukocytes to migrate out of blood into tissues enables them to perform their surveillance functions. Understanding the molecular mechanisms by which this migration is accomplished has the potential of unveiling new methods of regulating immune responses. The existing knowledge of rodent physiology and the recent development of knockout mice makes rodents attractive models for studying the mechanisms of leukocyte migration in vivo. This review considers the existing rodent models in light of the knowledge gained from them in lymphocyte migration, and in addition, shows the advantages and limitations of using rodent models in studying lymphocyte migration.
白细胞从血液迁移到组织中的能力使其能够执行监测功能。了解这种迁移得以实现的分子机制，有可能揭示调节免疫反应的新方法。啮齿动物生理学的现有知识以及基因敲除小鼠的最新发展，使啮齿动物成为研究体内白细胞迁移机制的有吸引力的模型。本文综述根据从啮齿动物模型中获得的关于淋巴细胞迁移的知识，对现有啮齿动物模型进行了考量，此外，还展示了使用啮齿动物模型研究淋巴细胞迁移的优缺点。
