Patel Kamala D, Cuvelier Susan L, Wiehler Shahina
Department of Physiology and Biophysics, University of Calgary, Alberta, Canada.
Semin Immunol. 2002 Apr;14(2):73-81. doi: 10.1006/smim.2001.0344.
Selectins are multi-functional adhesion molecules that mediate the initial interactions between circulating leukocytes and the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. This review will examine the selectins and their ligands with a focus on recent findings using knockout technology as well as the emerging role of selectins as signalling molecules.
选择素是多功能黏附分子，介导循环白细胞与内皮细胞之间的初始相互作用。十多年前首次被发现以来，选择素为诸多领域提供了深入见解，这些领域涵盖正常淋巴细胞归巢、炎症反应期间白细胞募集、碳水化合物配体生物合成以及黏附介导的信号传导等。本综述将探讨选择素及其配体，重点关注利用基因敲除技术的最新研究结果以及选择素作为信号分子的新作用。
