Crijns F R, Wolffenbuttel B H, De Mey J G, Struijker Boudier H A
Department of Endocrinology and Metabolism, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands.
Am J Physiol. 1999 May;276(5):H1672-7. doi: 10.1152/ajpheart.1999.276.5.H1672.
Diabetes induces hemodynamic and biochemical changes that can influence mechanical properties of arteries. Structure and mechanics of mesenteric small arteries were investigated in rats with streptozotocin-induced diabetes (duration 7-9 wk). The external diameter of mesenteric artery branches was measured in control (n = 9) and diabetic (n = 7) Wistar Rp rats at baseline and during pressurization in situ (0-150 mmHg) under normal and passive smooth muscle conditions. Mean arterial pressure and mesenteric artery pressure were not significantly different. Baseline mesenteric artery diameter was larger in the diabetes-induced group (439 +/- 12 vs. 388 +/- 18 micrometers, P < 0.05). Media cross-sectional area of arteries from diabetic rats was not significantly increased (0.0149 +/- 0.0015 vs. 0.0122 +/- 0.0007 mm2). Cross-sectional compliance was significantly increased in diabetic rats at intraluminal pressures ranging from 25 to 75 mmHg (P < 0.005), whereas cross-sectional distensibility was not modified. Wall tension and circumferential wall stress were increased in diabetes. These results indicate that mesenteric small arteries of diabetic rats display eutrophic outward remodeling associated with increased wall tension and circumferential wall stress.
糖尿病会引发血流动力学和生化变化，进而影响动脉的力学特性。研究了链脲佐菌素诱导的糖尿病大鼠（病程7 - 9周）肠系膜小动脉的结构和力学。在正常和被动平滑肌条件下，于基线状态及原位加压（0 - 150 mmHg）过程中，测量了对照（n = 9）和糖尿病（n = 7）Wistar Rp大鼠肠系膜动脉分支的外径。平均动脉压和肠系膜动脉压无显著差异。糖尿病诱导组的基线肠系膜动脉直径更大（439 ± 12对388 ± 18微米，P < 0.05）。糖尿病大鼠动脉的中膜横截面积无显著增加（0.0149 ± 0.0015对0.0122 ± 0.0007平方毫米）。在管腔内压力为25至75 mmHg范围内，糖尿病大鼠的横截面积顺应性显著增加（P < 0.005），而横截面积扩张性未改变。糖尿病时壁张力和周向壁应力增加。这些结果表明，糖尿病大鼠的肠系膜小动脉表现出与壁张力和周向壁应力增加相关的营养性外向重塑。
