Wirbelauer C, Iven H, Bastian C, Laqua H
Augenklinik, Medizinische Universität zu Lübeck, Germany.
J Cataract Refract Surg. 1999 May;25(5):648-51. doi: 10.1016/s0886-3350(99)00005-x.
To evaluate the systemic concentrations of lidocaine after intracameral injection of a 1% solution during cataract surgery and the safety of this application mode.
Department of Ophthalmology, Medical University of Lübeck, Lübeck, Germany.
This prospective study included 10 patients who had phacoemulsification and posterior chamber lens implantation with a self-sealing scleral tunnel incision. Topical anesthesia was achieved using cocaine 10% eyedrops combined with 0.5mL of unpreserved lidocaine 1% injected into the anterior chamber. Blood samples were taken from all patients at predetermined intervals before and during the procedure. Consecutive analysis for lidocaine was performed with gas chromatography.
In all samples, serum lidocaine concentrations were below a minimum detectable level of 100 ng/mL. No local or systemic intraoperative or postoperative complications were noted.
Intracameral injection of 0.5 mL lidocaine 1% revealed no systemic therapeutic concentrations. In patients in whom other forms of needle-delivered local anesthesia are contraindicated, intracameral injection of lidocaine should be considered to enhance topical anesthesia.
评估白内障手术期间前房内注射1%利多卡因溶液后的全身血药浓度以及这种给药方式的安全性。
德国吕贝克吕贝克医科大学眼科。
这项前瞻性研究纳入了10例行超声乳化白内障吸除术及后房型人工晶状体植入术并采用自闭式巩膜隧道切口的患者。使用10%可卡因滴眼液联合0.5mL未加防腐剂的1%利多卡因注入前房进行表面麻醉。在手术前和手术过程中的预定时间间隔采集所有患者的血样。采用气相色谱法对利多卡因进行连续分析。
在所有样本中，血清利多卡因浓度均低于最低可检测水平100 ng/mL。未观察到局部或全身术中或术后并发症。
前房内注射0.5mL 1%利多卡因未显示出全身治疗浓度。对于禁忌其他形式针剂局部麻醉的患者，应考虑前房内注射利多卡因以增强表面麻醉效果。
