Okamoto M, Rosenberg H C, Boisse N R
Eur J Pharmacol. 1976 Nov;40(1):107-19. doi: 10.1016/0014-2999(76)90360-5.
Experiments were performed to provide a quantitative description of the barbiturate withdrawal syndrome. Physical dependence was produced in 63 cats by 'maximally tolerable' dosing with sodium pentobarbital. After 5 weeks of chronic treatment each animal was placed in an activity monitoring cage and observed closely for signs of barbiturate abstinence. Electroencephalographic monitoring of sleep--wake cycles was performed in 5 of these cats. Most withdrawal signs appeared in 12-18 h and rapidly intensified. These included signs of neural hyper-excitability that involved motor, autoncidence, severity and time course of many withdrawal signs. 26 animals (41%) died during abstinence, usually during or immediately following grand mal type convulsions. The importance of quantitating withdrawal phenomena is discussed with respect to investigation of the requirements for physical dependency production, comparison of different drug dependencies, and pre-clinical evaluation of potential treatments of sedative-hypnotic dependence.
进行实验以对巴比妥类药物戒断综合征进行定量描述。通过用戊巴比妥钠进行“最大耐受量”给药，使63只猫产生身体依赖性。经过5周的慢性治疗后，将每只动物置于活动监测笼中，并密切观察巴比妥类药物戒断的迹象。对其中5只猫进行了睡眠-觉醒周期的脑电图监测。大多数戒断症状在12至18小时内出现并迅速加剧。这些症状包括神经兴奋性增高的迹象，涉及运动、自主神经、严重程度以及许多戒断症状的时间进程。26只动物（41%）在戒断期间死亡，通常是在大发作型惊厥期间或之后立即死亡。讨论了对戒断现象进行定量对于研究身体依赖性产生的要求、比较不同药物依赖性以及对镇静催眠药依赖性潜在治疗方法的临床前评估的重要性。
