两种五肽对各种离体平滑肌制剂的缓激肽增强活性。

The bradykinin potentiating activity of two pentapeptides on various isolated smooth muscle preparations.

作者信息

Ufkes J G, Aarsen P N, Van Der Meer C

出版信息

Eur J Pharmacol. 1976 Nov;40(1):137-44. doi: 10.1016/0014-2999(76)90363-0.

Abstract

Two bradykinin potentiating peptides A-VI5 (Val-Glu-Ser-Ser-Lys) and BPP5a (Pyr-Lys-Trp-Ala-Pro), were compared with respect to their potentiation of a number of different bradykinin effects on six isolated smooth muscle preparations. Apart from the considerable difference in effective concentrations, no essential qualitative difference was observed between these two peptides. Therefore the assumption of a different mechanism of action for the two peptides, which have a completely different structure, could not be substantiated.

摘要

比较了两种缓激肽增强肽A-VI5（缬氨酸-谷氨酸-丝氨酸-丝氨酸-赖氨酸）和BPP5a（焦谷氨酸-赖氨酸-色氨酸-丙氨酸-脯氨酸）对六种离体平滑肌制剂上多种不同缓激肽效应的增强作用。除有效浓度存在显著差异外，未观察到这两种肽之间存在本质的定性差异。因此，无法证实结构完全不同的这两种肽具有不同作用机制的假设。