Su C Y, Lin C P, Wang H Z, Su M Y, Tsai R K, Wu K Y, Sheu M M
Department of Ophthalmology, Kaohsiung Medical College, Taiwan, Republic of China.
Kaohsiung J Med Sci. 1999 Apr;15(4):218-25.
In this study, we investigate the efficacy and safety of intraocular use of fluconazole in the treatment of ocular fungal infection. Ten patients with intraocular fungal infections were examined. Among these patients, eight were infected with keratomycosis with intraocular spreading, one had postoperative fungal endophthalmitis after cataract operation with an intraocular lens implant, and another suffered from endogenous fungal endophthalmitis. In addition to the conventional local application with or without systemic administration of antifungal drugs, all ten patients were treated with intraocular administration of 5-10 micrograms/ml of fluconazole. The ocular fungal infections resolved in nine patients without obvious side effect. One failed in the antifungal treatment with loss of vision. In our experience, the results revealed that fluconazole is a safe and effective antifungal agent that can be administered intraocularly. We suggest that intraocular administration of this drug could be considered as an alternative or additional choice for the treatment of severe ocular fungal infections.
在本研究中，我们调查了眼内使用氟康唑治疗眼部真菌感染的疗效和安全性。对10例眼内真菌感染患者进行了检查。在这些患者中，8例感染角膜真菌病并伴有眼内播散，1例在白内障手术并植入人工晶状体后发生术后真菌性眼内炎，另1例患有内源性真菌性眼内炎。除了常规局部应用或联合全身应用抗真菌药物外，所有10例患者均接受了眼内注射5-10微克/毫升氟康唑的治疗。9例患者的眼部真菌感染得到解决，且无明显副作用。1例抗真菌治疗失败，视力丧失。根据我们的经验，结果显示氟康唑是一种可眼内给药的安全有效的抗真菌药物。我们建议，对于严重眼部真菌感染的治疗，可考虑将该药眼内给药作为一种替代或补充选择。
